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Fiona Watt, FRS FMedSci (born 28 March 1956) is a British scientist who is internationally known for her contributions to the field of stem cell biology. In the 1980s, when the field was in its infancy, she highlighted key characteristics of stem cells and their environment that laid the foundation [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis for much present day research.[1] She is currently director of the Centre for Stem Cells & Regenerative Medicine at King's College London, and Executive Chair of the MRC, the first woman to lead the MRC since its foundation in 1913.[2]
Watt was born on 28 March 1956[3] in Edinburgh, Scotland. [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis Her father was a dental surgeon who combined his clinical work with an active research programme. Her family were members of the Church of Scotland, and she attributes her commitment to public service to her Presbyterian upbringing. Her younger sister, Wendy, died in 1982. Fiona Watt knew she wanted to [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis be a scientist from a very young age. She is
quoted as saying, "I think that being a scientist is in a sense hardwired, and there are people who just couldn't conceive of being anything else".[4]
Fiona Watt obtained her Bachelor of Arts in Natural Sciences in 1976, and her [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis master's degree in 1979, both at Murray Edwards College, Cambridge University. She also obtained her Doctor of Philosophy (DPhil) from the Sir William Dunn School of Pathology, University of Oxford in 1979, supervised by Henry Harris, naming her thesis "Microtubule-organizing centres in cells in culture and in hybrids derived from [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis them".[5][6] Watt then completed a two-year postdoctoral research position at the Massachusetts Institute of Technology (MIT), US, with Dr. Howard Green. Two of her fellow postdocs, Bruce Spiegelman and Elaine Fuchs, were to remain lifelong friends. Upon returning to the UK, she founded her first lab at the Kennedy Institute [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis of Rheumatology in London where she became Head of the Molecular Cell Biology Laboratory. In 1987 she relocated to the
Cancer Research UK London Research Institute (now part of the Francis Crick Institute) where she served as Head of the Keratinocyte Laboratory. From 2007 to 2012 she worked in Cambridge, [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis where she helped to establish the Cambridge Cancer Research UK Institute and the Wellcome Trust Centre for Stem Cell Research. She was a Fellow of St John’s College and the first Herchel Smith Professor of Molecular Genetics at Cambridge University.
Moving to King’s College London in 2012, she set up [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis the internationally renowned Centre for Stem Cells and Regenerative Medicine (CSCRM) to promote collaboration between scientists and clinicians in order to progress the potential of stem cells into clinical reality for patients. By paying equal attention to architecture, infrastructure and recruitment she has created a unique research environment where research [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis can flourish.
Fiona Watt’s major research contribution has been to elucidate how the outer covering of mammalian skin, the epidermis, is maintained through self-renewal of stem cells and terminal differentiation
of their progeny. Using cultured human epidermis and genetically modified mice, she pioneered the identification of stem cell populations and [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis elucidated the roles of integrin,[7] Notch,[8] Wnt[9] and receptor tyrosine kinase[10] signalling in regulating their behavior. She identified the first marker, integrin extracellular matrix (ECM) receptors, that could be used to isolate epidermal stem cells[11] – researchers have subsequently found that this marker enriches for stem cells in a wide [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis range of tissues. In addition, others have amply confirmed her original concept that the ECM is a key component of the stem cell niche.
Her lab's research has also shown that the interplay between diverse intrinsic and extrinsic signals is central to determining cell fate,[12] identified different sensing mechanisms and [{Scaricare}] Disegno con le dita. Ediz. illustrata Download PDF EPUB Gratis downstream signalling pathways,[13] and elucidated the nature of the switch between stem cells and differentiated cells.[14]
A pioneer of single cell gene expression profiling,[15] she demonstrated that different human epidermal stem cell states are not stochastic but reflect the existence
of stem
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